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Calcium Channel SNPs & Neuro Disorders

Regulation of N-type voltage-gated calcium channels and presynaptic function by cyclin-dependent kinase 5.  Su SC, Seo J, Pan JQ, Samuels BA, Rudenko A, Ericsson M, Neve RL, Yue DT, Tsai LH.  Neuron 2012 Aug 23;75(4):675-87. (PMC Journal- In Process).

CACNA1C  (calcium channel, voltage-dependent, L type, alpha 1C subunit)  Risk Variant and Amygdala Activity in Bipolar Disorder, Schizophrenia and Healthy Controls http://www.plosone.org/article/info:doi/10.1371/journal.pone.0056970 “These results indicate that CACNA1C SNP rs1006737 affects amygdala activity during emotional processing across all diagnostic groups. The current findings add to the growing body of knowledge of the pleiotropic effect of this polymorphism, and further support that ion channel dysregulation is involved in the underlying mechanisms of BD and SZ.”

Major channels involved in neuropsychiatric disorders and therapeutic perspectives. http://www.ncbi.nlm.nih.gov/pubmed/23675382   “First, CACNA1C and ANK3 genes are involved in glutamatergic signaling which is integral to normal neuronal function (Wilson et al., 2006)…population studies support the association of polymorphisms in calcium and potassium channels with the genetic risk for bipolar disorders (BPDs) or schizophrenia. Moreover, point mutations in calcium, sodium, and potassium channel genes have been identified in some childhood developmental disorders. Finally, antibodies against potassium channel complexes occur in a series of autoimmune psychiatric diseases…healthy individuals carrying the SNP rs1006737 showed increased hippocampal activity in response to emotional stimuli…Cav1.2 channel plays important roles in remote spatial memories and fear memory extinction ( Bader et al., 2011).

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